Life science research (genomics, proteomics, metabolomics, glycomics)
Life Science and biotechnology include research areas such as proteomics, genomics and metabolomics. In addition, pharmaceutical companies require analytical and testing instruments that meet the needs of the modern age by helping to manufacture safe pharmaceuticals in compliance with IQ/OQ requirements and other applicable regulations.
We are actively supporting life science and biotech research as well as pharmaceutical R&D and Quality Control laboratories in in wide variety of areas such as impurity analysis, heavy metals, active pharmaceutical ingredients (API), organic solvents and residual solvent analysis, cleaning validation, solubility, crystal structure, stability testing, stereoisomer analysis, friability, viscosity, density measurements, contamination control and sterilisation solutions for GMP areas, life science research areas such as proteomics, genomics and metabolomics.
| Field | Applications and Analysis | Products | |
| Drug Discovery | Basic drug discovery and research | MALDI-TOFMS, LCMSMS, GCMS, IMScope, MultiNA | |
|
Low-Molecular Weight Pharmaceuticals |
Drug Discovery and Chemistry (Synthesis and Purification) |
Drug discovery and chemical research | PrepLC, SALD |
| Synthesis | HPLC, LCMSMS | ||
| Impurities analysis | Co-Sense, LCMS-IT-TOF, ICP | ||
| CMC (Development, Formulation, Production QA/QC) | Analytical method development | HPLC, GC | |
| Pharmaceutical formulation inversitgations | Thermal Analyzers, SALD | ||
| Impurity analysis | Co-Sense, LCMS-IT-TOF, HS-GC, HS-GCMS | ||
| Elution tests | HPLC, UV | ||
| Biopharmaceuticals | Drug Discovery | Structural analysis | MALDI-TOFMS, HPLC, LCMS-IT-TOF |
| Culture solution analysis | |||
| CMC (Development, Formulation, Production QA/QC) | Analytical method development | HPLC, PPSQ, SALD | |
| Farmakokinetics, Metabolomix, Safety | PK/TK ADME | HPLC, LCMSMS, IMScope | |
| Production | Cleaning validation | TOC, UV, HPLC | |
Life science research (genomics, proteomics, metabolomics, glycomics)
Drug discovery (biomarker discovery, screening and synthesis);
Pharmaceutical development (pre-clinical, toxicology, pharmacology, formulation, process)
Drug metabolism (ADME, DMPK)
Production and QA/QC (quality control and quality assurance) process
Biopharmaceuticals (protein characterization, impurity analysis)
OTC drugs/natural products
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Introduction As cells do not grow in isolation, traditional two-dimensional (2D) cell culture monolayer models lack physiologically relevant environmental conditions and can have drastic differences in terms of their physical and biochemical features, compared to intact biological systems. Since more physiologically relevant animal studies are time consuming and expensive, there is a need for experimental models that span the gap between in vitro cell-based assays and in vivo animal studies.
This application note demonstrates the benefits of using the Invitrogen™ Human TNFα Instant ELISA™ Kit with the Thermo Scientific™ Multiskan™ Sky Microplate Spectrophotomer and Wellwash™ Versa™ Microplate Washer. In addition, we show how to streamline the workflow by incorporating a preprogrammed pipetting protocol developed with the My Pipette™ Creator app and a Thermo Scientific™ E1-ClipTip™ Bluetooth™ electronic pipette.
A cell monolayer is treated with a dilution of a GFP-expressing virus. The cells are then coated with agar, which limits the virus spread to only neighboring cells.After incubation, GFP+ circles of infected cellsare counted for virus titration.
Related Instruments: Cytation 1, Cytation 5, Cytation 7, Lionheart FX, Lionheart LX, 405 TS, 405 LS
Infliximab, known commercially as Remicade, is a chimeric IgG1 kappa monoclonal antibody (mAb) that targets tumor necrosis factor-alpha (TNF).
In studies conducted, a significant number of patients (30-40%) who did not respond to anti-TNF treatment were identified.
Instrument: LCMS-8060 Liquid Chromatography Mass Spectrometer (LCMSMS)
Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It additionally acts as a disintegrant and tablet binder.
The revision to the harmonized standard for Povidone has been approved and Formic Acid in Povidone is now required to be measured.
The wound healing or "scratch" assay is one of the most highly used in vitro methods to monitor and quantify collective cell migration.
Instrument: Scratch Assay Starter Kit
Pharmaceuticals and Human Science: This issue focuses on Pharmaceuticals and Human Science, and contains such articles as follows:
An interview with Professor van Breemen, who is studying medicinal properties of natural products at the University of Illinois, College of Pharmacy, in Chicago, using advanced mass spectrometry
Professor van Breemen's latest work of the effect of human exposure to bisphenol A in the environment
Two interviews with Japanese pharmaceutical companies about Shimadzu's new technologies i-PDeA and i-DReC and technical reports of each technology
In addition, it contains information on other applicable topics, as well as the latest news and applications.
The aim of this study was to investigate the relationship between significant antioxidative metabolism in mice and to demonstrate the extent of oxidative damage over 8-hydroxy-2-deoxyguanosine (8-OHdG).
Instrument: LCMS-8040 Liquid Chromatography Mass Spectrometer (LCMSMS)
Determination of genotoxic impurities in 2D-LCMSMS (Co-Sense) system.
Instrument: LCMS-8040 Liquid Chromatography Mass Spectrometer (LCMSMS)
Determination of adhesion of brass starch with centrifugal force.
Instrument: Hitachi Koki CS-FNX series / S110AT
Think big see beyond... Ant Teknik is is offering sales, service and spare part supply; validation, application and training as well your turn-key laboratory project services for research and QC laboratories...
What is m/z? what does S/N ratio mean? What does is included in OQ? Explore answers to the most common questions we get from analysts…
Tips from our experts on chromatography, spectroscopy and sample preparation that you can benefit from in analytical laboratory...
