Thermo Fisher Scientific

HyPerforma™ Rocker Bioreactor

The Thermo Scientific HyPerforma Rocker Bioreactor brings control and measurement to rocking bioreactor applications. The rocker is controlled by a HyPerforma G3Lab Controller and TruBio software, providing a complete solution for research, process development, or seed train production applications.
The rocker is compatible with a 10 L, 20 L or 50 L Thermo Scientific Rock-it BioProcess Container (BPC), which provides from 5 L to 25 L of working volume and integrates a novel TruFluor pH+dO2 sensor for combined pH, DO , and temperature monitoring.

Applications
• Suspension and adherent cell culture processes
• Fermentation processes
• PD scale to full cGMP manufacturing workflows

Key Features

  • Compatible with most cell culture applications
  • Rocking motion is customizable to your specific workflow—from a smooth waveform that minimizes shear forces for sensitive cell lines, through four intermediate steps, to an aggressive motion that maximizes oxygen transfer for robust cells with high oxygen demands
  • Quick, simple setup with G3Lab Controller and TruBio Software Optional tray adapter allows the use of 10 L and 20 L BPCs
  • Each Rocker BPC is available in 10, 20, and 50 L sizes and is delivered with all relevant certificates, gammairradiated (25 to 40 kGy) and conforming to USP Class 6 specifications
  • Standard service packages
  • cGMP-compliant capabilities
  • Load cell for weight control
  • The pH+dO2 sensor provides measurement and control of critical process parameters: pH, DO, and temperature









 


TruBio Bioprocess Automation and Control Software

TruBio Bioprocess Automation and Control Software The TruBio software provides easy-to-configure process control, eliminating the need to learn automation control programming. Developed for use with HyPerforma Bioprocess Controllers, TruBio software is designed to support easy scaling and technology transfer and building of sophisticated process control strategies.
It also provides the flexibility to incorporate a wide range of cell culture, fermentor, or mixing vessels, and manage multiple data streams from several unit operations. TruBio software is powered by the Emerson DeltaV system, has been developed according to Good Automated Manufacturing Practice (GAMP™) 5 methods, and conforms to regulatory requirements for use in cGMP-compliant processes.

  • For non-GMP research and process development applications: Thermo Scientific™ TruBio™ Discovery Bioprocess Control Software powered by the Emerson™ DeltaV™ Discovery platform
  • For GMP and typical scale-up to manufacturing applications: TruBio software powered by the conventional DeltaV platform
 

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