Ergonomic and Elegant Tank Design

The S.U.B. is elegant in design while being extremely functional, and it is designed to meet cGMP requirements. The S.U.B. tank provides operator ergonomics, a small footprint, and easy cleaning capabilities associated with an open-cart frame.

• Helps save precious lab space with a minimized vessel footprint
• Easier access to harvest lines with the open-frame design
• Reduced hold-up volumes with the smartly designed tank floor
• Simple bag loading with a vertical access door (available on 500, 1,000, and 2,000 L sizes; electromechanical hoist provided on the 2,000 L S.U.B.)
• Pneumatic motor lift assembly for the 1,000 and 2,000 L sizes is used to lower the impeller for proper mixing when 20% of the fill volume is utilized

Efficient and Fast

The water jacket design allows fast heat-up and cool-down times, reducing process cycle time. The bottom water-jacketed systems increase surface area, improving heat transfer from low-volume cultures.

• Optional precision load cells and standard sight-volume indicators allow you to keep your processes running efficiently.
• Optional brushless DC motor includes encoder feedback for improved rpm accuracy and is compatible with ground-fault circuit interrupters (GFCIs)
• 3/8 in. dimple jacket improves flow rate through the water jacket for higher-performance temperature control
• Graduated sight-volume indicators accommodate visual volume references at a glance

Features

• Unique proprietary mixing system that enables conventional overhead mixing while maintaining sterility and integrity of the S.U.B. BioProcess Container (BPC)
• Largest qualified standard component library, which allows for customization of S.U.B. BPCs
• Minimized vessel footprint and reduced hold-up volumes
• Offered with AC or DC motors designed for precise agitation control
• Optional cable management tree provides line set and cabling organization for ease of use
• Load cells offered as standard feature with analog or digital communication options
• Option to use industry-leading single-use and traditional sensors for pH, DO, and pressure monitoring
• Option to choose the bioreactor vessel as a stand-alone system or a complete turnkey system with dedicated controls from either the Finesse™ or Applikon™ families of control systems for bioproduction. These systems work on PC, Delta V™, Allen-Bradley™, or Siemens™ software platforms.

• Updated 5:1 mixing turn-down ratio in combination with patented cross-flow sparger technology introduces gas just above liquid’s surface—to facilitate efficient mass transfer CO2 stripping, and reduce bubble sparging and associated foam damage to cells. This feature allows customers to do more with fewer vessels—which improves productivity and reduces costs simultaneously.

Motor Lift for 1,000–2,000 L Systems

HyPerforma S.U.B. Condenser System

The Thermo Scientific™ HyPerforma™ Single-Use Bioreactor (S.U.B.) condenser system supports the effective use of the Thermo Scientific™ HyPerforma™ 2,000 L S.U.B. It is also available as an auxiliary product for all other S.U.B. systems. It efficiently condenses exhaust gases and transfers condensate back into the bioreactor, preventing potential vent filter blockage and reducing fluid loss due to evaporation. It is offered in both single and double chill-plate formats.

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