POROS™ MabCapture™ A Select Resin

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Thermo Fisher Scientific

POROS™ MabCapture™ A Select Resin

POROS™ MabCapture™ A Select Resin is a new high-throughput, lower-priced Protein A chromatography resin, combining past improvements to MabCapture A with our own Protein A ligand, enabling the same high-throughput purification performance at a significant reduction in price over most Protein A chromatography resins.
These advances provide a monoclonal antibody purification resin that demonstrates high dynamic binding performance at low linear flow rates and maintains superior binding capacity at high linear flow rates where other chromatography media products cannot operate.

Technical Specifications
Application Note

With POROS MabCapture A Select affinity chromatography resin you can:
• Maintain high dynamic binding capacity at linear flow rates over 700 cm/hr
• Design processes with greater flexibility (shorter bed heights, faster flow rates, or both) due to the improvements made to the antibody binding efficiency
• Obtain the highest dynamic binding capacity for antibodies vs. conventional agarose- or silica-based Protein A resins
• Purify for polyclonal IgG from human, rabbit, monkey, mouse, pig, dog, or cat serum
• Clean and sanitize with standard sodium hydroxide agents used for other chromatography products
• Recognize major increases to process productivity and reduce the downstream bottleneck

Properties of POROS Chromatography Resins

Poly (styrene-divinylbenzene) backbone - provides linear and scalable performance. The beads are highly robust and chemically stable, providing thorough cleaning when needed.

Large through pores - provide a lower mass transfer resistance compared to other resins available. Capacity and resolution are maintained at a wide range of linear speeds, making the purification process more efficient.

50 micron bead size - provides superior resolution.
The smaller particle size (50 microns) results in narrower peaks and smaller elution volumes, helping to overcome tank size limitations on a larger scale.

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